FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
SCIENCE AT A GLANCE FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) is generally regarded as an immunologically ‘cold’ tumor type, devoid of CD8 T- cell infiltration and unresponsive to single- agent immunotherapy. Findings identify a novel role for focal adhesion kinase (FAK) in regulating the antigenicity…