SCIENCE AT A GLANCE FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) is generally regarded as an immunologically ‘cold’ tumor type, devoid of CD8 T- cell infiltration and unresponsive to single- agent immunotherapy. Findings identify a novel role for focal adhesion kinase （FAK） in regulating the antigenicity…
SCIENCE AT A GLANCE Cyanostrainchip : a Novel DNA Microarray Tool for High-Throughput Detection of Environmental Cyanobacteria at the Strain Level Cyanobacteria in environments is an important concern due to their crucial roles in ecosystems. A novel DNA microarray tool, termed CyanoStrainChip, is developed which enables strain-level comprehensive profiling of environmental cyanobacteria. Nearly all major…
SCIENCE AT A GLANCE Evolution of human H3N2 influenza virus Receptor specificity has substantially expanded the receptor-binding domain site Hemagglutinins (HAs) from human influenza viruses adapt to glycans on human airway cells to transmit within the human population. Glycan microarrays comprising various N- and O-linked glycans and glycolipids provide insights into the receptor-binding specificities of…
SCIENCE AT A GLANCE Integrated analysis of natural glycans using a versatile pyrazolone-type heterobifunctional tag ANPMP Glycans mediate various biological processes through carbohydrate-protein interactions, and glycan microarrays have become indispensable tools for understanding these mechanisms. However, advances in functional glycomics are hindered by the absence of convenient and universal methods for obtaining natural glycan libraries…
SCIENCE AT A GLANCE Machine-learning Assisted Influenza Vaccine Strain Selection framework Vaccines are the main pharmaceutical intervention used against the global public health threat posed by influenza viruses. Machine-learning Assisted Influenza VaccinE Strain Selection framework, MAIVeSS, can potentially reduce the optimal vaccine candidate selection time from months to days and thus facilitate timely supply of…
SCIENCE AT A GLANCE Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to tissue-resident alveolar macro-phages (TR-AM) in the inflamed lung. German scientists found that regenerative BMDM and TR-AM highly express Placenta-expressed transcript 1 (Plet1). Plet1…