SCIENCE AT A GLANCE Surface Glycans of Microvesicles Derived from Endothelial Cells, as Probed Using Plant Lectins In contrast to exosomes, glycomic studies of microvesicles are largely absent. This study presents a comprehensive analysis of the glycoprofiles of microvesicles (MVs) derived from endothelial EA.hy 926 cells, by plant lectins. The glycan profiles of the MVs…
SCIENCE AT A GLANCE Divergent Enzymatic Assembly of a Comprehensive 64-Membered IgG N-Glycan Library for Functional Glycomics Immunoglobulin G One of the most common antibodies presented primarily in the blood and tissues, plays a significant role in physiological and pathological activities. It has been discovered that IgG comprises a conserved N-glycosylation site at Asn297 in…
SCIENCE AT A GLANCE Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin Since the 1968 “Hong Kong flu” pandemic, H3N2 subtype of influenza A virus has been circulating in human for over half a century. As the major antigen of influenza virus, hemagglutinin (HA) glycoprotein is the fastest evolving…
SCIENCE AT A GLANCE Decoding complexity in biomolecular recognition of DNA i-motifs with microarrays The three-dimensional structure of the genome has a major impact on gene expression. Predominantly, the human genome consists of duplex B-form DNA though it can also adopt several non-B conformations including DNA intercalated-motif (i-Motif). i-Motifs are formed by C-rich DNA sequences…
SCIENCE AT A GLANCE Anti-neuronal antibodies against brainstem antigens are associated with COVID-19 Understanding how SARS-CoV-2 affects respiratory centers in the brainstem may help to preclude assisted ventilation for patients in intensive care setting. Researchers used peptide microarrays to screen serum and CSF samples from COVID-19 patients admitted to intensive care and compared with controls…