Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

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SCIENCE AT A GLANCE Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to tissue-resident alveolar macro-phages (TR-AM) in the inflamed lung. German scientists found that regenerative BMDM and TR-AM highly express Placenta-expressed transcript 1 (Plet1). Plet1…

Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts

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SCIENCE AT A GLANCE Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts The recognition of bacterial surfaces by viruses and the immune system is well documented, but the means by which bacterial predators recognize prey and engage in envelope traversal without causing lysis has remained obscure until…

Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens

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SCIENCE AT A GLANCE Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens Scientists at Calviri and MD Anderson Cancer Center, have studied a distinct source of cancer-specific biomarkers: antibodies to neoantigens generated by translation of RNA-level errors. In all cells, errors in RNA transcription and processing occur more than 100-fold more…

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

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SCIENCE AT A GLANCE  Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency Patients with autosomal recessive NIK or RELB deficiency, or a specific type of autosomal-dominant NF-κB2 deficiency, have neutralizing autoantibodies against type I IFNs and are at higher risk of getting life-threatening COVID-19 pneumonia. In contrast to patients with autoimmune…

WHOLE SLIDE IMAGING – FROM THE MICROSCOPE GLASS SLIDE TO THE DIGITAL IMAGES

Articles, Corporate

Digital pathology (DP), also known as virtual microscopy or whole slide imaging (WSI), is an alternative to conventional microscopy. Beyond enabling a fully digital workflow for anatomical pathology departments, this technology consists of digitizing a glass slide to produce a digital image.  This technology therefore meets the needs of microscope users who seek to visualize…