Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

Articles

SCIENCE AT A GLANCE Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to tissue-resident alveolar macro-phages (TR-AM) in the inflamed lung. German scientists found that regenerative BMDM and TR-AM highly express Placenta-expressed transcript 1 (Plet1). Plet1…

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Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts

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SCIENCE AT A GLANCE Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts The recognition of bacterial surfaces by viruses and the immune system is well documented, but the means by which bacterial predators recognize prey and engage in envelope traversal without causing lysis has remained obscure until…

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Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens

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SCIENCE AT A GLANCE Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens Scientists at Calviri and MD Anderson Cancer Center, have studied a distinct source of cancer-specific biomarkers: antibodies to neoantigens generated by translation of RNA-level errors. In all cells, errors in RNA transcription and processing occur more than 100-fold more…

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Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

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SCIENCE AT A GLANCE  Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency Patients with autosomal recessive NIK or RELB deficiency, or a specific type of autosomal-dominant NF-κB2 deficiency, have neutralizing autoantibodies against type I IFNs and are at higher risk of getting life-threatening COVID-19 pneumonia. In contrast to patients with autoimmune…

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AACR 2024 in San Diego

Events

We’re thrilled to announce that INNOPSYS will be showcasing at the prestigious AACR Annual Meeting from April 7th to April 10th in San Diego!  Catch us at booth #214 and discover our products with Joséphine ZEIGER, Laurence BOUET et Perrine BOREL. Don’t miss this opportunity to network with industry experts, explore groundbreaking research, and learn…

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